Single Choice

The reactivities of acid halides (I), anhydrides (II), esters (III) and amides (IV) with nucleophilic reagents follow the order :

AI > II > III > IV
Correct Answer
BIV > III > II > I
CI > III > II > IV
DIII > II > I > IV

Solution

The reactivity of carboxylic acid derivatives towards nucleophile substitutions is related to the electronegative leaving group's ability to activate the carbonyl. The more electronegative leaving groups withdraw electron density from the carbonyl, therby increasing its electrophilicity.

In this case the reactivity order is as follows:
I > II > III > IV

Hence the correct option is 'A' .

SIMILAR QUESTIONS

Physical World

Mark the correct order of increasing reactivity:

Physical World

Arrange the following compounds in the increasing order of their property as indicated: Acetaldehyde, acetone, di-tert-butyl ketone, methyl tert- butyl ketone (reactivity towards HCN).

Physical World

In which option first one is more reactive than second in each pair towards $$S_{N}2$$ reaction ?

Physical World

Which of the most reactive acid derivative?

Physical World

Which among the following ester is most reactive towards nucleophilic attack?

Physical World

Which of the following compounds will be most easily hydrolysed?

Physical World

Fill in the blanks: (S) Acetic anhydride is ..... reactive than acetyl chloride.

Physical World

Answer the following with reasoning:- (v) How the order of reactivity of the acid derivatives is related to the base strength of the leaving group?

Physical World

Answer the following with reasoning:- (ix) Why a ketone is not isolated from the reaction of an ester on equivalent of RMgX?

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