Subjective Type

A single base mutation in a gene may not 'always' result in loss or gain of function. Do you think the statement is correct? Defend your answer.

Solution

A single base mutation is also called point mutation. A point mutation can bring a change in the reading frame of the mRNA by tRNA due to an insertion or deletion of a base, resulting in formation of a defective protein. However, certain point mutations that involve replacing (substituting) a base may not result in production of a fault protein because genetic code is degenerate, that is, a single amino acid is coded by more than one codon. This form of mutation is also referred to a silent mutation.
Example, Lysine is represented by two codons TTC and TTT
So, if mutation occurs from C to T then the amino acid added to the polypeptide chain will still be the same. In this type of mutation, a functional protein is formed.

SIMILAR QUESTIONS

Genetics

Which of the following statement is not true for cancer cells in relation to mutations?

Genetics

Which one of the following is a wrong statement regarding mutations?

Genetics

What would happen, if in a gene encoding a polypeptide of 50 amino acids, $$25^{th}$$ codon (UAU) is mutated to UAA?

Genetics

Choose the correct answer from the alternatives given : A DNA sequence undergoes three subsequent point mutations which result in subsequent changes in transcription of mRNA as shown below: Original mRNA : AUG CAU CUC ACG GAU UAG Point mutation 1: AUG CAU CUU ACG GUA UAG Point mutation 2 : AUG CAU GCU UAC - GGU AUA Point mutation 3 : AUG CAU GCU UAA GGU AUA Select the correct sequence of point mutations that occurred in the DNA.

Genetics

The mutation of a purine to a pyramidine is known as

Genetics

Enzymes X catalyzes hydrolysis of GTP into GDP. The GTP-bon from of Z transmits a signal that leads to cell proliferation. The GDP-bound from does not transmit any such signal. Mutations in X are in many cancers. Which of the following alterations of X are most likely to contribute to cancer ?

Genetics

Why is nascent oxygen supported to be toxic to aerobic life forms?

Genetics

The sites in the gene at which the mutations occur with unusually high frequency are referred to as

Genetics

Type of gene mutation which involves replacement of purine with pyrimidine or vice versa or the substitution of one type of base with another type of base is

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