Genetics
Which one of the following is a wrong statement regarding mutations?
Which of the following statement is not true for cancer cells in relation to mutations?
Protooncogenes are the genes that regulate the normal functioning of the cell cycle (the orderly series of event that leads to the formation of daughter cells by parent cell and is under the regulation of several check points). Mutation in proto-oncogenes produces oncogenes that cause loss of control over cell cycle and uncontrolled and repetitive entry of cell in cell cycle thereby forming tumors. This makes option A incorrect. Option C is incorrect as carcinogenic mutations inactivate the check points and cause loss of control over cell cycle. Option B is incorrect as these mutations inhibit the telomerase inhibitor and thereby make the cells immortal. Telomerase enzyme is responsible for replication of telomeres to help cells to maintain the chromosome length. Option D is correct as carcinogenic mutations accelerate the synthesis of telomerase enzymes as inhibition of its synthesis may cause cell death due to gradual shortening of chromosomes during each replication cycle.
Which one of the following is a wrong statement regarding mutations?
What would happen, if in a gene encoding a polypeptide of 50 amino acids, $$25^{th}$$ codon (UAU) is mutated to UAA?
Choose the correct answer from the alternatives given : A DNA sequence undergoes three subsequent point mutations which result in subsequent changes in transcription of mRNA as shown below: Original mRNA : AUG CAU CUC ACG GAU UAG Point mutation 1: AUG CAU CUU ACG GUA UAG Point mutation 2 : AUG CAU GCU UAC - GGU AUA Point mutation 3 : AUG CAU GCU UAA GGU AUA Select the correct sequence of point mutations that occurred in the DNA.
The mutation of a purine to a pyramidine is known as
Enzymes X catalyzes hydrolysis of GTP into GDP. The GTP-bon from of Z transmits a signal that leads to cell proliferation. The GDP-bound from does not transmit any such signal. Mutations in X are in many cancers. Which of the following alterations of X are most likely to contribute to cancer ?
Why is nascent oxygen supported to be toxic to aerobic life forms?
A single base mutation in a gene may not 'always' result in loss or gain of function. Do you think the statement is correct? Defend your answer.
Frame shift mutation occurs when
The sites in the gene at which the mutations occur with unusually high frequency are referred to as
Type of gene mutation which involves replacement of purine with pyrimidine or vice versa or the substitution of one type of base with another type of base is